Food For Cardiovascular Health


Say It Ain't Soy!


Yes, but this soybean is different! What makes it different is 
simple. After hours of fermentation, the boiled soybeans 
metamorphose to an ancient medicinal food called "natto" 
pronounced "nah'-toe." Natto may just be the "perfect food," 
producing 18 valuable amino acids and an enzyme nattokinase 
that may challenge the pharmaceutical industry's best "blood-
clot busters." Natto, which has recently attracted attention 
throughout the world, is the third most popular type of fermented 
soybean in the Japanese diet. Japan has the highest average 
longevity in the world, which may partly be attributed to a high 
consumption of natto. 

When compared with ordinary soybeans, the natto produces more 
calories, protein, fiber, calcium, potassium and vitamin B2. Its 
high protein and economical price in terms of protein per gram 
has earned it the sobriquet "hata-ke no niko," or meat of the 
field. This nickname appears well deserved, as in comparison with 
an equivalent amount of beef, natto has slightly less protein 
(16.5 grams to 21 .2 grams), but contains more carbohydrates and 
fiber, and is also higher in calcium, phosphorous, iron and vitamin 
B2. Plus, it has nearly double the calcium and far more vitamin E 
to boot. 

According to legend, the first person to originate traditional 
Japanese natto was the famous warrior Yoshiie Minamoto during the 
Heian era of Japanese history (794-1192 A.D.). The horse was extremely 
important to the Japanese samurai warrior of the period, and great 
care was given to provide suitable provisions for the horses when 
armies were on the move. Typically, boiled soybeans were cooled down, 
dried in the sun and packed immediately in rice straw bags for 
transport with the army. If the army was on a rapid deployment, the 
boiled soybeans were packed hastily into the rice straw bags without 
cooling or drying. The rice straw just happened to contain a harmless 
and naturally occurring microorganism, Bacillus subtilis that fermented 
the soybeans and produced natto with its characteristic sticky texture.


Initially, the soybeans were presumed to have spoiled until Yoshiie 
Minamoto observed that his horses were "picky eaters" and demonstrated 
a preference for the "spoiled"soybeans or natto. One day, Minamoto 
demonstrated tremendous courage and dipped his finger into the seemingly 
"rotten goo." To his astonishment, the fermented soybeans were not only 
edible but had a distinct Umami flavor. Minamoto was responsible for 
introducing natto to northwestern Japan, where he ruled. To this day 
natto is especially popular in that region of Japan as a folk remedy 
for fatigue, beriberi, dysentery, heart and vascular diseases. 

The most distinctive features of natto are the adhesive surrounding the 
soybeans and the strong flavor. The sticky material has been shown to 
consist of poly-g-glutamic acid (D and L) and polysaccharides (levan-
form fructan), and the strong "cheese-like" flavor is due to the presence 
of pyrazine. These features sometimes make it hard for some people, 
especially people from other countries, to accept natto; however, these 
are the main factors which give natto the outstanding properties. Natto, 
which has recently attracted attention throughout the world, is a familiar 
part of the Japanese diet.


Technical Aspects of Nattokinase


Nattokinase produces a prolonged action in two ways: it prevents the 
formation of thrombi and it dissolves existing thrombus. Nattokinase 
orally administrated to twelve healthy adults indicated elevations of 
the breakdown products of the fibrin and the ability of the blood to 
break down fibrin called euglobulin fibrinolytic activity (EFA). These 
results suggest the ability of nattokinase to accelerate fibrinolysis 
in the blood for a prolonged period of time. FDP levels in the adults 
drastically increased 4 hours after the administration of the nattokinase, 
indicating that fibrin within the blood vessels is gradually being 
dissolved with repeated intake of nattokinase. By measuring EFA & FDP 
levels, the activity of nattokinase has been determined to last from 8 to 
12 hours. An additional parameter for confirming the action of nattokinase 
following oral administration is a rise in blood levels of tissue 
plasminogen activator (TPA) antigen, which indicates a release of TPA from 
the endothelial cells and/or the liver and the endogenous production of 
plasmin (the body?s blood clotting buster).6, 7 
In 1995, researchers from Miyazaki Medical College and Kurashiki University 
of Science and Arts in Japan studied the effects of nattokinase on blood 
pressure in both animal and human subjects. In addition, the researchers 
confirmed the presence of inhibitors of angiotensin converting enzyme (ACE) 
within the test extract, which consisted of 80% ethanol extract of 
lyophilized viscous materials of natto. ACE causes blood vessels to narrow 
and blood pressure to rise - by inhibiting ACE; nattokinase has a lowering 
effect on blood pressure.1, 2 

The same natto extract was then tested on human volunteers with high blood 
pressure. Blood pressure levels were measured after 30 grams of lyophilized 
extract (equivalent to 200 grams of natto food) was administered orally for 
4 consecutive days. In 4 out of 5 volunteers, the systolic blood pressure 
(SBP) decreased on average from 173.8 + 20.5 mmHg to 154.8 + 12.6 mmHg. 
Diastolic blood pressure (DBP) decreased on average from 101.0 + 11.4 mmHg 
to 91.2 + 6.6 mmHg. On average, this data represents a 10.9 percent drop in 
SBP and a 9.7 percent drop in DBP.1, 2,6


References:


1-Natto-Traditional Japanese Fermented Soy Beans with Recently Discovered 
Health Benefits and Novel Industrial Applications, Enzyme Wave, Volume 3, 
June 2002, Amano Enzyme, Inc., page 2-4. 

2-Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly 
Blood Clots in Hours. Health Sciences Institute, March 2002. 

3-Maruyama M, Sumi H. Effect of Natto Diet on Blood Pressure. JTTAS, 1995. 

4-Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic 
activity in plasma by oral administration of nattokinase. Acta Haematol 1990;
84(3): 139-43. 

5-Sumi H, Hamada H, Mihara H. A novel strong fibrinolytic enzyme (nattokinase) 
in the vegetable cheese ?natto." International Journal of Fibronolysis and 
Thrombolysis. Abstracts of the ninth international congress on fibrinolysis, 
Amsterdam, 1988, Vol.2, Sup.1:67. 

6-Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic 
enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular 
soybean food in the Japanese diet. Experientia 1987, Oct 
15;43(10):1110-1. 7-Sumi H. Healthy Microbe ?Bacillus natto". Japan Bio 
Science Laboratory Co. Ltd.


Disclaimer:  The above article is for informational purposes only and is 
not intended to diagnose or treat a particular illness.  The reader  is 
encouraged to seek the advice of a holistically competent licensed professional 
health care provider.  The  information in this article has not been evaluated 
by the Food and Drug Administration.  This product is not intended to diagnose, 
treat, cure or prevent any disease.






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